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J DeGroot Selected Research

type 2 alpha 1 Collagenopathy

12/2009Combined role of type IX collagen and cartilage oligomeric matrix protein in cartilage matrix assembly: cartilage oligomeric matrix protein counteracts type IX collagen-induced limitation of cartilage collagen fibril growth in mouse chondrocyte cultures.
11/2006Biochemical and functional modulation of the cartilage collagen network by IGF1, TGFbeta2 and FGF2.
12/2000Effect of collagen turnover on the accumulation of advanced glycation end products.
9/2000Age-related accumulation of Maillard reaction products in human articular cartilage collagen.

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J DeGroot Research Topics

Disease

10Osteoarthritis
07/2012 - 06/2001
4type 2 alpha 1 Collagenopathy
12/2009 - 09/2000
4Rheumatoid Arthritis
01/2008 - 11/2003
3Inflammation (Inflammations)
04/2007 - 03/2004
2Hip Osteoarthritis (Coxarthrosis)
07/2012 - 05/2010
2Neoplasm Metastasis (Metastasis)
12/2003 - 06/2002
2Colorectal Neoplasms (Colorectal Cancer)
12/2003 - 06/2002
1Disease Susceptibility (Diathesis)
10/2010
1Osteophyte
11/2008
1Pain (Aches)
11/2008
1Chondrocalcinosis (Pseudogout)
05/2005
1Arthritis (Polyarthritis)
05/2005
1Multiple Organ Failure (MODS)
08/2004
1Necrosis
03/2004
1Joint Diseases (Joint Disease)
03/2004
1Root Caries
01/2003
1Neoplasms (Cancer)
06/2002
1Wounds and Injuries (Trauma)
04/2002

Drug/Important Bio-Agent (IBA)

9Matrix Metalloproteinases (MMPs)IBA
01/2008 - 06/2002
5Biomarkers (Surrogate Marker)IBA
07/2012 - 03/2004
3pentosidineIBA
03/2012 - 09/2000
3Proteins (Proteins, Gene)FDA Link
07/2010 - 12/2000
3Pregnancy-Associated alpha 2-Macroglobulins (alpha 2 Macroglobulin)IBA
01/2008 - 11/2003
3CollagenIBA
06/2001 - 09/2000
2Cartilage Oligomeric Matrix ProteinIBA
07/2010 - 12/2009
2Matrix Metalloproteinase 2 (Gelatinase A)IBA
12/2003 - 06/2002
2Advanced Glycation End ProductsIBA
11/2001 - 09/2000
1ORALIT (ORS)IBA
10/2010
1Collagen Type IXIBA
12/2009
1Methotrexate (Mexate)FDA LinkGeneric
01/2008
1Leflunomide (Arava)FDA LinkGeneric
01/2008
1Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
11/2006
1prostromelysinIBA
05/2005
1Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA
05/2005
1diphosphoric acid (pyrophosphoric acid)IBA
05/2005
1Tissue Inhibitor of Metalloproteinase-1IBA
05/2005
1ZymosanIBA
08/2004
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2004
1Peptide Hydrolases (Proteases)FDA Link
01/2003
1GelatinIBA
06/2002
1Collagenases (Collagenase)FDA Link
04/2002
1Hyaluronoglucosaminidase (Hyaluronidase)FDA Link
04/2002
1Proteoglycans (Proteoglycan)IBA
04/2002
1Aspartic Acid (Aspartate)FDA Link
12/2000
1N(6)-(1-carboxyethyl)lysineIBA
09/2000
1Lysine (L-Lysine)FDA Link
09/2000
1N(6)-carboxymethyllysine (carboxymethyllysine)IBA
09/2000
1Arginine (L-Arginine)FDA Link
09/2000
1HydroxylysineIBA
09/2000

Therapy/Procedure

1Therapeutics
06/2002